A first-in-class regenerative scaffold to create functional muscle tissue.
Backed by university research, we’re creating a regenerative scaffold to rebuild muscle tissue after injury or damage and transform the standard of care for complex muscle repair.
Advantages of the Decellularized Muscle Matrix
Our patent-pending Decellularized Muscle Matrix (DMM) recreates muscle’s natural extracellular environment, providing the structural and chemical cues necessary for healing.
Outperformance
DMM regrows muscle better than collagen, the current standard of care. The muscle-specific scaffold is rich in bioactive cues to promote regeneration — not simply repair.
Growth & Support
Beyond muscle, DMM rebuilds blood vessels to keep tissues alive and supports peripheral nerve axons.
Research
Developed at Virginia Commonwealth University, DMM is supported by Department of Defense funding and is moving toward pre-clinical trials.
Sarcogenics Founder Michael McClure, Ph.D.
Our Research Plan
Sarcogenics is pioneering regenerative medicine solutions that restore muscle lost to trauma, surgery, or disease.
Establish: Sarcogenics is advancing toward pre-clinical and regulatory milestones with a clear path to commercialization via the FDA 510(k) pathway.
Develop: DMM is being tested on laboratory models to demonstrate effectiveness and comparisons to off-the-shelf products on the market.
Sustain: Testing has shown success in new muscle growth after two months, with potential indications that include supraspinatus muscle and tendon damage, stress and pelvic floor issues, and patch augmentation or interposition grafting.
Gallery: DMM in development at the Sarcogenics lab
How DMM Works
1
Remove cells, keep structure
Donor muscle tissue is processed to strip away all living cells, leaving behind the extracellular matrix — a natural scaffold made of proteins like collagen, laminin, and fibronectin.
2
Provide muscle-specific signals
This scaffold contains the physical alignment and chemical cues unique to skeletal muscle. These signals guide the body’s own stem cells and support blood vessel and nerve ingrowth essential for real muscle regeneration.
3
Regrow functional muscle
Once implanted, the scaffold integrates with the patient’s tissue. Instead of forming scar tissue, it stimulates new muscle fiber formation, restores neuromuscular connections, and improves strength and function in ways that standard grafts or collagen patches cannot.
The Market Opportunity
Before Sarogenics is a market that can transform the way physicians treat muscle-loss injuries. For interested investors, here’s a snapshot of the demand and revenue potential.
Initial Market: Military Trauma Treatment Facilities
Market Size: $7 billion
Annual Market Growth Rate: 6.7%
Our Team
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Michael J. McClure, Ph.D.
FOUNDER
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Geetanjali Bendale, Ph.D.
SCIENTIFIC ADVISER
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Daniel Delgado, Ph.D. Candidate
SCIENTIFIC ADVISER
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Seema Sood
BUSINESS ADVISER
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Richard Pellegrino
BUSINESS ADVISER
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William Jeranek, M.D.
CLINICAL ADVISER
The Science
Skeletal muscle is unique: Aligned fibers, satellite stem cells, and neuromuscular junctions allow for extraordinary regeneration. But in severe injuries, the muscle's capacity to regenerate is lost. The components of Sarcogenics’ Decullarized Muscle Matrix began in an academic laboratory and include:
Decellularized scaffold: A whole-muscle derived extracellular matrix stripped of immunogenic cells while preserving pro-regenerative architecture.
Neurotization compatibility: Enhances muscle innervation when combined with nerve transfers.
Cell delivery platform: Supports integration with adipose-derived stromal cells (ASCs) or myoblasts for added regenerative benefit.
Anti-aging strategies: Research shows donor tissue age and glycation affect outcomes; Sarcogenics is pioneering ways to overcome these barriers.
Join us in transforming recovery from muscle injury.
Sarcogenics is advancing toward preclinical and regulatory milestones with a clear path to commercialization via the FDA 510(k) pathway. Contact us to learn how you can join us on this journey.